Comedian, actress, and TV personality Rosie O’Donnell recently reflected on her considerable weight loss. The 63-year-old shared her recent photos online and explained her weight loss process and the impact of the medication, Mounjaro, on the same.
So, here’s everything fans need to know about O’Donnell’s recent photos and her physical transformation journey.
Rosie O’Donnell talks about her weight loss
The veteran TV personality took to social media and posted a photo of herself seemingly performing a stand-up routine, in which she looked noticeably thinner.
“I can’t believe this is me now #mounjaro #weightloss #bodydismorphia,” Rosie O’Donnell captioned the Instagram post, effectively implying that the drug Mounjaro was responsible for her dramatic weight loss. Since she shared the image, fans have left messages of support in the comment section of her post.
Check out O’Donnell’s post below:
In March 2025, O’Donnell shared a TikTok video in which she discussed why she relocated to Ireland earlier this year with her child, Clay, and how that positively impacted her lifestyle. “I’ve lost more weight here,” The View alum disclosed. “I am on Mounjaro for my diabetes, and one of the side effects is that you lose weight. But it’s also because I had a chef for over two years in Los Angeles, and I don’t have a chef now. It’s me cooking for Clay and me.”
O’Donnell further admitted that she herself was shocked by her transformation. “I’m one of those people who’s always had a weight issue and now that I’m a size large, instead of an XL or a XXL, I find it shocking. I really do. I find it completely shocking,” she revealed.
Notably, Mounjaro is a brand of the tirzepatide drug primarily used against type 2 diabetes in adults. Meanwhile, there is another brand of tirzepatide, called Zepbound. It has been approved by the FDA as a weight loss drug for adults.
Mounjaro reportedly doesn’t have any generic alternative and was approved by the FDA as a diabetes drug. It is a type of injection administered to patients weekly. Furthermore, patients are encouraged to exercise and make certain changes to their dietary habits.
